Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance
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چکیده
منابع مشابه
Spatial Colocalization of Human Ohnolog Pairs Acts to Maintain Dosage-Balance
Ohnologs -paralogous gene pairs generated by whole genome duplication- are enriched for dosage sensitive genes, that is, genes that have a phenotype due to copy number changes. Dosage sensitive genes frequently occur in the same metabolic pathway and in physically interacting proteins. Accumulating evidence reveals that functionally related genes tend to co-localize in the three-dimensional (3D...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2016
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msw108